Spag6l Gene Summary [Mouse]
Enables microtubule binding activity. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; plasma membrane bounded cell projection organization; and stress fiber assembly. Located in several cellular components, including cytoskeleton; lateral wall of outer hair cell; and sperm principal piece. Is expressed in cochlea. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spag6l |
| Official Name | sperm associated antigen 6-like [Source:MGI Symbol;Acc:MGI:1354388] |
| Ensembl ID | ENSMUSG00000022783 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 6-like |
| Synonyms | PF16, RGD1310892, Spag6, Spag6l1, sperm associated antigen 6-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag6l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Armadillo/beta-catenin-like repeat
- HEAT-like repeat
- Armadillo/beta-catenin-like repeats
- protein binding
- Adaptin N terminal region
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- manchette
- microtubules
- axonemes
- cytosol
- central apparatus
- acrosome
- cytoplasmic vesicles