Pspc1 Gene Summary [Mouse]
Enables RNA binding activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Located in paraspeckles. Is expressed in several structures, including central nervous system; genitourinary system; and sensory organ. Orthologous to human PSPC1 (paraspeckle component 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pspc1 |
| Official Name | paraspeckle protein 1 [Source:MGI Symbol;Acc:MGI:1913895] |
| Ensembl ID | ENSMUSG00000021938 |
| Bio databases IDs | |
| Aliases | paraspeckle protein 1 |
| Synonyms | 5730470C09Rik, LOC100912131, paraspeckle component 1, paraspeckle protein 1, PSP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pspc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- eNOPS_SF
- NOPS (NUC059) domain
- RNA recognition motif
- nuclear localization sequence
- coiled-coil domain
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- interchromatin space
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pspc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhythmic process
- negative regulation of transcription, DNA-dependent
- activation of innate immune response
- innate immune response
- regulation of transcription, DNA-dependent
- regulation of circadian rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- paraspeckles
- cytoplasm
- nuclear speck
- nuclear matrix
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding