Akap7 Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Located in nucleus. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including brain; cartilage; endocrine gland; genitourinary system; and trachea. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap7 |
| Official Name | A kinase (PRKA) anchor protein 7 [Source:MGI Symbol;Acc:MGI:1859150] |
| Ensembl ID | ENSMUSG00000039166 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 7 |
| Synonyms | 6430401D08, AI662165, AKAP15, AKAP18, AKAP18d, A-kinase anchoring protein 7, A kinase anchor protein 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoylation site
- AMP binding
- protein kinase A binding
- protein kinase binding
- myristoylation sequence
- AKAP7 2'5' RNA ligase-like domain
- protein domain specific binding
- leucine zipper domain
- protein binding
- PKA-RI-RII subunit binding domain of A-kinase anchor protein
Pathways
Biological processes and signaling networks where the Akap7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- peptic ulcer disease
- plasma cell myeloma
regulates
- K+
- cAMP-dependent protein kinase
- 2',5'-oligoadenylate
- ion
role in cell
- invasion by
- cell death
- migration
- survival
- targeting
- response by
- signal transduction in
- accumulation in
- action potential
- repolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- exocytic vesicle
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- sarcoplasmic reticulum
- cytosol
- apical membrane
- lateral plasma membrane
- dendrite initial segments
- synapse
- Z line
- transverse tubules
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- regulation of protein kinase A signaling cascade
- cellular response to cAMP
- protein localization
- regulation of synaptic transmission
- regulation of membrane repolarization
- regulation of action potential
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- lateral plasma membrane
- cytosol
- macromolecular complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein kinase binding
- protein binding
- protein kinase A regulatory subunit binding
- protein kinase A binding