Tulp3 Gene Summary [Mouse]
Predicted to enable several functions, including enzyme binding activity; intraciliary transport particle A binding activity; and phosphatidylinositol binding activity. Involved in protein localization to cilium. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and skeletal system development. Located in axoneme. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and genitourinary system. Used to study polycystic kidney disease. Orthologous to human TULP3 (TUB like protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tulp3 |
| Official Name | tubby-like protein 3 [Source:MGI Symbol;Acc:MGI:1329045] |
| Ensembl ID | ENSMUSG00000001521 |
| Bio databases IDs | |
| Aliases | tubby-like protein 3 |
| Synonyms | 2310022L06RIK, HRCDF, LOC100364088, RGD1560037, TUBL3, TUB like protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tulp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tub family
- Tubby N-terminal
- binding protein
- G-protein-coupled receptor binding
- enzyme binding
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ciliopathy
- hepatorenocardiac degenerative fibrosis
- cystic kidney disease
role in cell
- proliferation
- morphology
- signaling in
- loss
- loss in
- development
- length
- differentiation
- mitosis
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- non-motile cilium
- cilia
- Nucleus
- Plasma Membrane
- basal bodies
- axonemes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tulp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- embryonic camera-type eye development
- embryonic neurocranium morphogenesis
- anterior/posterior pattern specification
- regulation of transcription, DNA-dependent
- central nervous system neuron differentiation
- brain development
- regulation of G-protein coupled receptor protein signaling pathway
- bronchus morphogenesis
- negative regulation of smoothened signaling pathway
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- embryonic digit morphogenesis
- bone development
- neural tube closure
Cellular Component
Where in the cell the gene product is active
- nucleus
- cilium
- nucleolus
- extracellular region
- plasma membrane
- axoneme
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol binding
- enzyme binding