Senp2 Gene Summary [Mouse]
Enables deSUMOylase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle process. Located in nuclear body. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Senp2 |
| Official Name | SUMO/sentrin specific peptidase 2 [Source:MGI Symbol;Acc:MGI:1923076] |
| Ensembl ID | ENSMUSG00000022855 |
| Bio databases IDs | |
| Aliases | SUMO/sentrin specific peptidase 2 |
| Synonyms | 2310007L05RIK, 4930538C18Rik, AXAM, AXAM2, LOC78973, mKIAA1331, SMT3IP2, SUMO/sentrin specific peptidase 2, SUMO specific peptidase 2, SuPr-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Senp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- cysteine endopeptidase
- Axin binding domain
- catalytic domain
- peptidase
- protein domain specific binding
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Senp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- oral lichen planus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- oral leukoplakia
- hyperglycemia
- seborrheic dermatitis
- atrial ventricular block
role in cell
- expression in
- phosphorylation in
- activation in
- cell death
- differentiation
- binding
- myogenesis
- production in
- transcription in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
- nuclear bodies
- nuclear envelope
- nuclear lamina
- perinuclear vesicles
- cytoplasmic vesicles
- PML nuclear bodies
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Senp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- protein sumoylation
- protein desumoylation
- protein transport
- proteolysis
- positive regulation of protein ubiquitination
- Wnt receptor signaling pathway
- negative regulation of protein ubiquitination
- regulation of Wnt receptor signaling pathway
- fat cell differentiation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- PML body
- cytosol
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific protease activity
- SUMO-specific endopeptidase activity