Apoc4 Gene Summary [Mouse]
Predicted to be involved in positive regulation of triglyceride storage and triglyceride homeostasis. Part of very-low-density lipoprotein particle. Is expressed in liver. Orthologous to human APOC4 (apolipoprotein C4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apoc4 |
| Official Name | apolipoprotein C-IV [Source:MGI Symbol;Acc:MGI:87878] |
| Ensembl ID | ENSMUSG00000074336 |
| Bio databases IDs | |
| Aliases | apolipoprotein C-IV |
| Synonyms | Acl, APO-CIV, Apolipoprotein c2-linked, apolipoprotein C4, apolipoprotein C-IV, LOC686851 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apoc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- protein binding
- Apolipoprotein C4
- transporter
Pathways
Biological processes and signaling networks where the Apoc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apoc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- positive regulation of sequestering of triglyceride
- lipid metabolic process
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid transporter activity