Nup98

Predicted to enable several functions, including molecular condensate scaffold activity; nuclear localization sequence binding activity; and promoter-specific chromatin binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nucleocytoplasmic transport; positive regulation of mRNA splicing, via spliceosome; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in nucleus. Is expressed in several structures, including nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup98 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Nup98 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup98 gene, providing context for its role in the cell.