Tmem50b Gene Summary [Mouse]
Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; bone; brain; ganglia; and sensory organ. Orthologous to human TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem50b |
| Official Name | transmembrane protein 50B [Source:MGI Symbol;Acc:MGI:1925225] |
| Ensembl ID | ENSMUSG00000022964 |
| Bio databases IDs | |
| Aliases | transmembrane protein 50B |
| Synonyms | B230114J08Rik, C21orf4, HCVP7TP3, LOC654779, RGD1307561, transmembrane protein 50B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem50b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uncharacterized protein family (UPF0220)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem50b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- late endosome to vacuole transport via multivesicular body sorting pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding