Ncaph2 Gene Summary [Mouse]
This gene encodes a component of the condensin-2 complex. The encoded protein may regulate the structure of mitotic chromosomes. Loss of function of this gene disrupts T-cell development. There are two pseudogenes for this gene on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | Ncaph2 |
| Official Name | non-SMC condensin II complex, subunit H2 [Source:MGI Symbol;Acc:MGI:1289164] |
| Ensembl ID | ENSMUSG00000008690 |
| Bio databases IDs | |
| Aliases | non-SMC condensin II complex, subunit H2 |
| Synonyms | 384D8-2, CAPH2, HCAP-H2, KLEISIN-beta, KLEISIN-β, non-SMC condensin II complex subunit H2, non-SMC condensin II complex, subunit H2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncaph2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Condensin II complex subunit CAP-H2 or CNDH2, mid domain
- protein binding
- Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
- Condensin II complex subunit CAP-H2 or CNDH2, C-term
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- hematological neoplasia
- kidney carcinoma
- renal cancer
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
- lymphomagenesis
role in cell
- differentiation
- meiosis
- condensation
- condensation in
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytoplasmic bridges
- chromosome
- nucleoplasm
- germinal vesicles
- kinetochores
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncaph2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
- T cell differentiation in thymus
- female meiosis chromosome separation
- mitotic sister chromatid separation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- membrane
- cell junction
- condensin complex
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding