Scaf4 Gene Summary [Mouse]
Predicted to enable RNA binding activity and RNA polymerase II C-terminal domain phosphoserine binding activity. Predicted to be involved in mRNA processing and negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SCAF4 (SR-related CTD associated factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Scaf4 |
| Official Name | SR-related CTD-associated factor 4 [Source:MGI Symbol;Acc:MGI:2146350] |
| Ensembl ID | ENSMUSG00000022983 |
| Bio databases IDs | |
| Aliases | SR-related CTD-associated factor 4 |
| Synonyms | FZS, SFRS15, SRA4, SR-related CTD-associated factor 4, Srsf15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scaf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- KLF1_2_4_N
- VHS, ENTH and ANTH domain superfamily
- enzyme binding
- CID domain
- protein binding
- phosphoprotein amino acid binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scaf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding