Rad18 Gene Summary [Mouse]
Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including negative regulation of DNA recombination; response to UV; and spermatogenesis. Located in XY body; chromatin; and male germ cell nucleus. Is expressed in several structures, including adrenal medulla; dorsal root ganglion; testis; trunk mesenchyme derived from neural crest; and urinary system. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad18 |
| Official Name | RAD18 E3 ubiquitin protein ligase [Source:MGI Symbol;Acc:MGI:1890476] |
| Ensembl ID | ENSMUSG00000030254 |
| Bio databases IDs | |
| Aliases | RAD18 E3 ubiquitin protein ligase |
| Synonyms | 2810024C04Rik, hHR18, hRAD18, RAD18 E3 ubiquitin protein ligase, Rad18sc, RNF73 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- DNA repair protein rad18
- SAP motif
- Rad18-like CCHC zinc finger
- SAP domain
- Rad6-binding domain
- DNA secondary structure binding
- Ring finger domain
- protein binding
- identical protein binding
- DNA polymerase eta binding domain
- binding protein
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Takayasu arteritis
- organismal death
- uterine leiomyoma
- leiomyomatosis
- wheeze
role in cell
- proliferation
- expression in
- accumulation in
- phosphorylation in
- survival
- cell death
- number
- radiosensitivity
- activation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- centrosome
- nuclear foci
- nucleoplasm
- nuclear bodies
- sex chromatin
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chromosome segregation
- DNA repair
- response to DNA damage stimulus
- protein monoubiquitination
- postreplication repair
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- replication fork
- nuclear inclusion body
- nucleus
- centrosome
- site of double-strand break
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- polyubiquitin binding
- Y-form DNA binding
- damaged DNA binding
- single-stranded DNA binding