LIMA1 Gene Summary [Human]
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | LIMA1 |
| Official Name | LIM domain and actin binding 1 [Source:HGNC Symbol;Acc:HGNC:24636] |
| Ensembl ID | ENSG00000050405 |
| Bio databases IDs | |
| Aliases | LIM domain and actin binding 1, epithelial protein lost in neoplasm beta |
| Synonyms | EPLIN, LDLCQ8, LIM domain and actin binding 1, SREBP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIMA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- actin monomer binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
- Serine Proline motif
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cardiovascular disorder
- hypertension
- colorectal carcinoma
- colorectal carcinomagenesis
- schizophrenia
- colorectal cancer
- breast cancer
- breast carcinoma
- endometrium tumor
role in cell
- expression in
- invasion by
- formation
- formation in
- growth
- quantity
- proliferation
- migration
- invasiveness
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cytoskeleton
- focal adhesions
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- cytosol
- actin stress fibers
- brush border
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIMA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of actin filament depolymerization
- ruffle organization
- cholesterol metabolic process
- intestinal cholesterol absorption
- cell migration
- cholesterol homeostasis
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- focal adhesion
- cleavage furrow
- stress fiber
- ruffle
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- metal ion binding
- cadherin binding
- actin monomer binding