Amhr2 Gene Summary [Mouse]
Predicted to enable several functions, including anti-Mullerian hormone receptor activity; protein homodimerization activity; and transforming growth factor beta receptor activity, type II. Acts upstream of or within sex differentiation. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including bone; early embryo; forebrain; genitourinary system; and spinal cord lumbar region. Used to study persistent Mullerian duct syndrome. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amhr2 |
| Official Name | anti-Mullerian hormone type 2 receptor [Source:MGI Symbol;Acc:MGI:105062] |
| Ensembl ID | ENSMUSG00000023047 |
| Bio databases IDs | |
| Aliases | anti-Mullerian hormone type 2 receptor |
| Synonyms | AMHR, anti-Mullerian hormone receptor type 2, anti-Mullerian hormone type 2 receptor, C14, Misiir, MISR2, MIS receptor, MISRII, MRII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amhr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- transforming growth factor-beta receptor
- Protein Kinases, catalytic domain
- type II transforming growth factor-beta receptor
- protein homodimerization
- protein-hormone receptor
- TFP
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Amhr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pseudohermaphroditism
- persistent Müllerian duct syndrome
- hyperplasia
- persistent Mullerian duct syndrome type II
- familial premature ovarian failure
- secondary sex reversal
- osteogenesis imperfecta type III
regulates
- synthetic promoter
- CDKN2A
- reporter gene
role in cell
- activation in
- development
- abnormal morphology
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum/Golgi apparatus fractions
- cell surface
- perinuclear region
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amhr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sex differentiation
- blood vessel development
- male gonad development
- cellular response to growth factor stimulus
- BMP signaling pathway
- transforming growth factor beta receptor signaling pathway
- female gonad development
- protein phosphorylation
- Mullerian duct regression
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- metal ion binding
- hormone binding
- transforming growth factor beta-activated receptor activity
- transforming growth factor beta receptor activity, type II