Kcnn4

Enables intermediate conductance calcium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Acts upstream of or within several processes, including cell volume homeostasis; phospholipid translocation; and saliva secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytosol. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including alimentary system; liver; metanephros; nervous system; and skeleton. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; hypertension; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Kcnn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnn4 gene, providing context for its role in the cell.