Cxcl13 Gene Summary [Mouse]
Enables CXCR5 chemokine receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer's patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl13 |
| Official Name | chemokine (C-X-C motif) ligand 13 [Source:MGI Symbol;Acc:MGI:1888499] |
| Ensembl ID | ENSMUSG00000023078 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 13 |
| Synonyms | 4631412M08RIK, ANGIE, ANGIE2, BCA-1, BLC, BLR1L, CXC CHEMOKINE, C-X-C motif chemokine ligand 13, SCYB13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- fibroblast growth factor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- CXCR3 chemokine receptor binding
- receptor agonist activity
- cytokine
- heparin binding
- CXCR chemokine receptor binding
Pathways
Biological processes and signaling networks where the Cxcl13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- endometriosis
- lung cancer
- squamous cell cancer of the oral cavity
- Sjögren syndrome
- dextran sodium sulfate-induced colitis
- rheumatoid arthritis
- immune thrombocytopenia
- early missed abortion
- systemic lupus erythematosus
role in cell
- expression in
- activation in
- phosphorylation in
- quantity
- binding
- adhesion
- migration
- ubiquitination in
- tyrosine phosphorylation in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcl13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
- regulation of angiogenesis
- cell surface receptor signaling pathway
- defense response to bacterium
- elevation of cytosolic calcium ion concentration
- chronic inflammatory response
- germinal center formation
- inflammatory response
- immune response
- regulation of humoral immune response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- lymphocyte chemotaxis across high endothelial venule
- positive regulation of T cell chemotaxis
- endothelial cell chemotaxis to fibroblast growth factor
- neutrophil chemotaxis
- negative regulation of endothelial cell chemotaxis to fibroblast growth factor
- positive regulation of integrin activation
- positive regulation of cell-cell adhesion mediated by integrin
- B cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR10 chemokine receptor binding
- CXCR5 chemokine receptor binding
- CXCR chemokine receptor binding
- receptor agonist activity
- heparin binding
- fibroblast growth factor binding
- CXCR3 chemokine receptor binding
- chemokine activity