Madcam1 Gene Summary [Mouse]
Predicted to enable integrin binding activity involved in cell-matrix adhesion. Acts upstream of or within keratinocyte differentiation and leukocyte migration. Predicted to be located in membrane. Is expressed in eyelid; hair follicle; and hemolymphoid system. Orthologous to human MADCAM1 (mucosal vascular addressin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Madcam1 |
| Official Name | mucosal vascular addressin cell adhesion molecule 1 [Source:MGI Symbol;Acc:MGI:103579] |
| Ensembl ID | ENSMUSG00000020310 |
| Bio databases IDs | |
| Aliases | mucosal vascular addressin cell adhesion molecule 1 |
| Synonyms | MACAM1, Madcam, MDCAM1, Mucosal addressin, mucosal vascular addressin cell adhesion molecule 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Madcam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adhesion molecule, immunoglobulin-like
- immunoglobulin domain
- cell adhesion molecule binding
- integrin binding
- Immunoglobulin like
Pathways
Biological processes and signaling networks where the Madcam1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- ulcerative colitis
- lung cancer
- severe active ulcerative colitis
- active severe colonic Crohn disease
- active moderate colonic Crohn disease
- moderate active ulcerative colitis
- Crohn disease of ileocolon
- pediatric ulcerative colitis
- ileal Crohn disease
role in cell
- migration
- differentiation
- binding
- adhesion
- number
- function
- cell tethering or rolling by
- migratory capacity
- recruitment
- depletion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Madcam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- positive regulation of leukocyte migration
- integrin-mediated signaling pathway
- immune response
- signal transduction
- cell adhesion
- leukocyte tethering or rolling
- receptor clustering
- heterotypic cell-cell adhesion
- positive regulation of lymphocyte migration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane