Pcbp4 Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity. Acts upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator and negative regulation of mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; lung; metanephros; and sensory organ. Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcbp4 |
| Official Name | poly(rC) binding protein 4 [Source:MGI Symbol;Acc:MGI:1890471] |
| Ensembl ID | ENSMUSG00000023495 |
| Bio databases IDs | |
| Aliases | poly(rC) binding protein 4 |
| Synonyms | 1200003L19Rik, AlphaCP-4, CBP, LIP4, MCG10, poly(rC) binding protein 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- protein binding
- K homology RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- early missed abortion
role in cell
- expression in
- apoptosis
- proliferation
- growth
- cell cycle progression
- senescence
- G2/M phase transition
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of nuclear mRNA splicing, via spliceosome
- regulation of mRNA stability
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- mRNA binding
- mRNA 3'-UTR binding