Ipo7 Gene Summary [Mouse]
Enables histone binding activity. Involved in negative regulation of osteoblast differentiation; positive regulation of odontoblast differentiation; and positive regulation of protein localization to nucleus. Acts upstream of or within innate immune response and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO7 (importin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ipo7 |
| Official Name | importin 7 [Source:MGI Symbol;Acc:MGI:2152414] |
| Ensembl ID | ENSMUSG00000066232 |
| Bio databases IDs | |
| Aliases | importin 7 |
| Synonyms | A330055O14Rik, C330016G14, Imp7, IMPORTIN 7, LOC102553567, RANBP7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ipo7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- histone binding
- GTPase regulator
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- insomnia
- lymphomagenesis
- lymphoma
role in cell
- accumulation in
- activation in
- proliferation
- invasion by
- binding in
- migration
- growth
- differentiation
- aggregation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ipo7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- protein import into nucleus
- innate immune response
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- membrane
- cytosol
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- histone binding
- small GTPase binding
- GTPase regulator activity