Taf8 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity. Acts upstream of or within inner cell mass cell proliferation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in several structures, including Harderian gland; brain; early conceptus; genitourinary system; and tongue. Orthologous to human TAF8 (TATA-box binding protein associated factor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf8 |
| Official Name | TATA-box binding protein associated factor 8 [Source:MGI Symbol;Acc:MGI:1926879] |
| Ensembl ID | ENSMUSG00000023980 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 8 |
| Synonyms | II, NEDMLHB, TAF, TAF(II)43, TAFII-43, TATA-box binding protein associated factor 8, TBN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- histone fold domain (HFD) superfamily
- TATA Binding Protein (TBP) Associated Factor 8
- protein binding
- Bromodomain associated
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy
- neurodevelopmental disorder
- sporadic amyotrophic lateral sclerosis
regulated by
- adipocytes
- 3T3-L1 cells
- CCNK
- 2-amino-5-phosphonovaleric acid
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- DNA-dependent transcriptional open complex formation
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- inner cell mass cell proliferation
- cell differentiation
- regulation of fat cell differentiation
- transcription initiation from RNA polymerase II promoter
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- perinuclear region of cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity