Taf9 Gene Summary [Mouse]
Enables DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in brain; genitourinary system; limb; tail; and thymus primordium. Orthologous to human TAF9 (TATA-box binding protein associated factor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf9 |
| Official Name | TATA-box binding protein associated factor 9 [Source:MGI Symbol;Acc:MGI:1888697] |
| Ensembl ID | ENSMUSG00000052293 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 9 |
| Synonyms | 2310012M09Rik, 4921516M08RIK, CINAP, MGC:5067, STAF31/32, TAF2G, TAFII-31, TAFII-32, TAFIID32, TATA-box binding protein associated factor 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- Transcription initiation factor IID, 31kD subunit
- CENP-S protein
- transcription regulator
- histone acetyltransferase
- transcription co-activator
- nucleic acid binding
- transcription factor binding
- protein domain specific binding
- p53 binding
- protein binding
- CR domain
- sequence-specific DNA binding
- DNA binding
- histone fold domain (HFD) superfamily
- ATPase binding
- double-stranded DNA binding
- tail domain
- p53-binding domain
- Bromodomain associated
Pathways
Biological processes and signaling networks where the Taf9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- chronic kidney disease
- nonalcoholic fatty liver disease
regulates
- CXCL8
- TP53
- DNA promoter
- DNA endogenous promoter
- synthetic promoter
- reporter gene
- RNA polymerase II
- HAMP
role in cell
- apoptosis
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of response to cytokine stimulus
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- RNA polymerase II transcriptional preinitiation complex assembly
- box C/D snoRNP assembly
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- negative regulation of apoptotic process
- response to interleukin-1
- protein stabilization
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- pre-snoRNP complex
- SAGA complex
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- histone acetyltransferase activity
- p53 binding
- protein binding
- transcription coactivator activity
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- C2H2 zinc finger domain binding
- transcription regulatory region sequence-specific DNA binding
- ATPase binding