Tspo2 Gene Summary [Mouse]
Enables cholesterol binding activity. Involved in enucleate erythrocyte differentiation; intracellular cholesterol transport; and lipid droplet organization. Located in endoplasmic reticulum. Is expressed in several structures, including jaw; liver; skeleton; and spleen. Orthologous to human TSPO2 (translocator protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tspo2 |
| Official Name | translocator protein 2 [Source:MGI Symbol;Acc:MGI:1917276] |
| Ensembl ID | ENSMUSG00000023995 |
| Bio databases IDs | |
| Aliases | translocator protein 2 |
| Synonyms | 2510027D20Rik, AC165291.2, BZRPL1, translocator protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family
- cholesterol binding
- protein binding
- monocarboxylic acid transporter
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular cholesterol transport
- enucleate erythrocyte differentiation
- lipid particle organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- organelle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding