Washc1 Gene Summary [Mouse]
Enables gamma-tubulin binding activity and phosphatidylinositol 3-kinase inhibitor activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; meiotic nuclear division; and oocyte maturation. Acts upstream of or within several processes, including low-density lipoprotein particle clearance; positive regulation of cholesterol import; and positive regulation of protein localization to cell surface. Located in autophagosome; centrosome; and endosome. Part of BLOC-1 complex and WASH complex. Is expressed in several structures, including brain; genitourinary system; immune system; liver; and lung. Orthologous to several human genes including WASHC1 (WASH complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Washc1 |
| Official Name | WASH complex subunit 1 [Source:MGI Symbol;Acc:MGI:1916017] |
| Ensembl ID | ENSMUSG00000024101 |
| Bio databases IDs | |
| Aliases | WASH complex subunit 1 |
| Synonyms | 1110049F14Rik, FAM39E, LOC102553152, LOC684479, LOC689385, ORF19, WASH, WASH1, Wash2, WASH complex subunit 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Washc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- ubiquitin protein ligase binding
- VCA domain
- alpha-tubulin binding
- phosphoinositide 3-kinase regulator
- protein binding
- low-density lipoprotein receptor binding
- WAHD domain of WASH complex
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- anemia
- cytopenia
role in cell
- disruption
- expression in
- maturation
- polymerization
- assembly
- morphology
- proliferation
- formation
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomes
- centrosome
- microtubules
- cytosol
- autophagic vacuoles
- recycling endosomes
- early endosomes
- late endosomes
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Washc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of pseudopodium assembly
- extracellular matrix disassembly
- protein transport
- retrograde transport, endosome to Golgi
- exocytosis
- negative regulation of autophagy
- Arp2/3 complex-mediated actin nucleation
- endosomal transport
- regulation of protein ubiquitination
- endocytic recycling
- regulation of Arp2/3 complex-mediated actin nucleation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- centriole
- late endosome
- cytosol
- recycling endosome
- WASH complex
- recycling endosome membrane
- autophagic vacuole
- exocyst
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- actin binding
- gamma-tubulin binding
- alpha-tubulin binding