Vps29 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Predicted to be involved in endocytic recycling; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within Golgi to vacuole transport. Part of retromer complex. Is expressed in cranial ganglion; dorsal root ganglion; and gonad. Orthologous to human VPS29 (VPS29 retromer complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps29 |
| Official Name | VPS29 retromer complex component [Source:MGI Symbol;Acc:MGI:1928344] |
| Ensembl ID | ENSMUSG00000029462 |
| Bio databases IDs | |
| Aliases | VPS29 retromer complex component |
| Synonyms | 2010015D08Rik, DC15, DC7, PEP11, Vps29 (predicted), VPS29 retromer complex component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoesterase, MJ0936 family
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
- Calcineurin-like phosphoesterase superfamily domain
- transporter
- Calcineurin-like phosphoesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- endosomes
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of autophagy
- retrograde transport, endosome to Golgi
- intracellular protein transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- intracellular membrane-bounded organelle
- retromer complex
- late endosome
- cytosol
- retromer complex, inner shell
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding