Meiob Gene Summary [Mouse]
Enables chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meiob |
| Official Name | meiosis specific with OB domains [Source:MGI Symbol;Acc:MGI:1922428] |
| Ensembl ID | ENSMUSG00000024155 |
| Bio databases IDs | |
| Aliases | meiosis specific with OB domains |
| Synonyms | 4930528F23Rik, C16orf73, gs129, LOC681837, meiosis specific with OB domains, meiosis specific with OB-fold, MLZ-675, POF23, SPGF22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Meiob often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- chromatin binding
- enzyme
- protein binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Meiob gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male meiosis
- male meiosis I
- double-strand break repair via homologous recombination
- fertilization
- resolution of meiotic recombination intermediates
- female meiosis I
- synapsis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromosome
Molecular Function
What the gene product does at the molecular level
- chromatin binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- single-stranded DNA binding