Stra8 Gene Summary [Mouse]
Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and germ cell development. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including 2-cell stage embryo; ganglia; gonad; mesonephros; and spleen primordium. Orthologous to human STRA8 (stimulated by retinoic acid 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stra8 |
| Official Name | stimulated by retinoic acid gene 8 [Source:MGI Symbol;Acc:MGI:107917] |
| Ensembl ID | ENSMUSG00000029848 |
| Bio databases IDs | |
| Aliases | stimulated by retinoic acid gene 8 |
| Synonyms | LOC346673, RGD1562852, stimulated by retinoic acid 8, stimulated by retinoic acid gene 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stra8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Stra8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
role in cell
- expression in
- meiosis
- replication in
- response by
- premeiotic phase
- lack
- replication
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stra8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- cellular response to retinoic acid
- oogenesis
- DNA replication
- spermatogenesis
- activation of meiosis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity