MEIOB Gene Summary [Human]
Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Predicted to be located in cytoplasm. Implicated in spermatogenic failure 22. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MEIOB |
| Official Name | meiosis specific with OB-fold [Source:HGNC Symbol;Acc:HGNC:28569] |
| Ensembl ID | ENSG00000162039 |
| Bio databases IDs | |
| Aliases | meiosis specific with OB-fold |
| Synonyms | 4930528F23Rik, C16orf73, gs129, LOC681837, meiosis specific with OB domains, meiosis specific with OB-fold, MLZ-675, POF23, SPGF22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEIOB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- chromatin binding
- enzyme
- protein binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEIOB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male meiosis
- male meiosis I
- double-strand break repair via homologous recombination
- fertilization
- resolution of meiotic recombination intermediates
- female meiosis I
- synapsis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromosome
Molecular Function
What the gene product does at the molecular level
- chromatin binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- single-stranded DNA binding