Myo1f Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; neutrophil degranulation; and positive regulation of neutrophil migration. Located in cortical actin cytoskeleton. Part of filamentous actin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human MYO1F (myosin IF). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo1f |
| Official Name | myosin IF [Source:MGI Symbol;Acc:MGI:107711] |
| Ensembl ID | ENSMUSG00000024300 |
| Bio databases IDs | |
| Aliases | myosin IF |
| Synonyms | C330006B10Rik, Myosin i, myosin IF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo1f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin and Kinesin motor domain
- protein binding
- Unconventional myosin tail, actin- and lipid-binding
- Myosin
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- metabolic syndrome X
- sepsis
- laser induced choroidal neovascularization
- COVID-19
- insulin-dependent diabetes mellitus
- familial nonsyndromic hearing impairment
- infection by HIV-1
role in cell
- activation in
- phosphorylation in
- migration
- extravasation
- migration by
- organization
- transmigration
- chemotaxis
- acetylation in
- reassembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- actin filaments
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo1f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament organization
- endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- microvillus
- actin cytoskeleton
- unconventional myosin complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- actin binding
- microfilament motor activity