Vps28 Gene Summary [Mouse]
This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Details
| Type | Retained Intron |
| Official Symbol | Vps28 |
| Official Name | vacuolar protein sorting 28 [Source:MGI Symbol;Acc:MGI:1914164] |
| Ensembl ID | ENSMUSG00000115987 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 28 |
| Synonyms | 1110014J03Rik, CIIA, D730005C08Rik, vacuolar protein sorting 28, VPS28 subunit of ESCRT-I, VPS protein HOMOLOG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VPS28 protein
- ubiquitin binding
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Vps28 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
role in cell
- growth
- apoptosis
- activation in
- cell death
- colony formation
- binding in
- degradation in
- migration
- assembly
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- endosomal membrane
- early endosomes
- exosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- positive regulation of protein catabolic process
- positive regulation of ubiquitin-dependent endocytosis
- negative regulation of protein ubiquitination
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- early endosome
- extracellular vesicular exosome
- endosome
- cytoplasm
- ESCRT I complex
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding