Gins2 Gene Summary [Mouse]
Predicted to be involved in DNA replication and double-strand break repair via break-induced replication. Predicted to be located in nucleus. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex subventricular zone; cortical plate; and heart. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gins2 |
| Official Name | GINS complex subunit 2 (Psf2 homolog) [Source:MGI Symbol;Acc:MGI:1921019] |
| Ensembl ID | ENSMUSG00000031821 |
| Bio databases IDs | |
| Aliases | GINS complex subunit 2 (Psf2 homolog) |
| Synonyms | 2210013I18Rik, 4833427B12Rik, GINS complex subunit 2, HSPC037, LOC51659, Pfs2, PSF2, RGD1311055 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gins2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-helical domain of GINS complex proteins (Sld5, Psf1, Psf2 and Psf3)
- GINS_B
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- plexiform neurofibroma
- colon epithelial cancer
- endometrial carcinoma
- epithelial endometrial cancer
- colon carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gins2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via break-induced replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- CMG complex
- GINS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding