Slc39a7 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Involved in B cell differentiation; skin epidermis development; and zinc ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a7 |
| Official Name | solute carrier family 39 (zinc transporter), member 7 [Source:MGI Symbol;Acc:MGI:95909] |
| Ensembl ID | ENSMUSG00000024327 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 7 |
| Synonyms | AGM9, D6S115E, D6S2244E, H2-KE4, HKE4, HLA CLASS II REGION EXPRESSED, KE4, RING5, RT1-KE4, solute carrier family 39 member 7, solute carrier family 39 (zinc transporter), member 7, ZIP7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- protein binding
- zinc ion transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc39a7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive agammaglobulinemia type 9
- mechanical hypersensitivity
- agammaglobulinemia
regulates
- heavy metal
- proinsulin
- Zn2+
role in cell
- cell death
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- cellular zinc ion homeostasis
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- zinc ion transmembrane transporter activity