Dnm3 Gene Summary [Mouse]
Predicted to enable several functions, including G protein-coupled glutamate receptor binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be a structural constituent of postsynapse. Involved in synaptic vesicle endocytosis. Located in photoreceptor inner segment. Is active in presynapse. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; musculature; and paraxial mesenchyme. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnm3 |
| Official Name | dynamin 3 [Source:MGI Symbol;Acc:MGI:1341299] |
| Ensembl ID | ENSMUSG00000040265 |
| Bio databases IDs | |
| Aliases | dynamin 3 |
| Synonyms | 9630020E24RIK, B230343F03Rik, C530045C17, DKFZP566K013, Dyn3, Dyn3 (aaa), Dyn3 (baa), Dyna III, dynamin-2, dynamin 3, KIAA0820, LOC171574, mKIAA0820 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynamin GTPase effector domain
- protein kinase binding
- G-protein-coupled receptor binding
- enzyme binding
- GTPase
- enzyme
- Proline-rich protein
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- identical protein binding
- proline rich domain
- Dynamin family
- Mucin-like
- GTPase domain
- Dynamin central region
- PH domain
- structural molecule
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Dnm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hyperglycemia
- Sézary syndrome
- breast carcinoma
- endometriosis
- COVID-19
- ovarian carcinoma
- epithelial ovarian cancer
- Moyamoya disease
- uterine leiomyoma
role in cell
- expression in
- quantity
- calcium response in
- formation in
- formation
- abnormal morphology
- internalization by
- morphogenesis
- accumulation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- microtubules
- cytosol
- synaptic membrane
- dendritic spines
- dendritic spine head
- synapse
- photoreceptor inner segments
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendritic spine morphogenesis
- synapse assembly
- synaptic vesicle budding from presynaptic membrane
- positive regulation of filopodium assembly
- endocytosis
- receptor internalization
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- perinuclear region of cytoplasm
- synaptic cleft
- extracellular vesicular exosome
- cytoplasm
- dendritic spine
- synapse
- axon
- plasma membrane
- microtubule
- dendritic spine head
Molecular Function
What the gene product does at the molecular level
- type 5 metabotropic glutamate receptor binding
- GTP binding
- protein binding
- GTPase activity
- type 1 metabotropic glutamate receptor binding
- nitric-oxide synthase binding
- microtubule binding