Lars Gene Summary [Mouse]
Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lars |
| Official Name | leucyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:1913808] |
| Ensembl ID | ENSMUSG00000024493 |
| Bio databases IDs | |
| Aliases | leucyl-tRNA synthetase |
| Synonyms | 2310045K21Rik, 3110009L02Rik, cLRS, hr025Cl, HSPC192, ILFS1, KIAA1352, LARS, leucyl-tRNA synthetase 1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucyl-tRNA synthetase, archaeal and cytosolic family
- glutamine-tRNA ligase
- GTPase activator
- enzyme
- protein binding
- leucine-tRNA ligase
- valyl-tRNA synthetase
- Anticodon-binding domain of tRNA ligase
- nucleotidyl transferase superfamily
- tRNA synthetases class I (I, L, M and V)
- class Ia aminoacyl tRNA synthetases anticodon binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- transient infantile liver failure
- acute myeloid leukemia
- infantile liver failure syndrome type 1
- infection by HIV-1
regulates
- tRNA-Leu
- MTORC1
- GTPase
role in cell
- activation in
- response by
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endomembrane system
- lysosome
- Endoplasmic Reticulum
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leucyl-tRNA aminoacylation
- cellular response to amino acid stimulus
- tRNA aminoacylation for protein translation
- cellular response to leucine
- cellular response to amino acid starvation
- regulation of cell size
- glutaminyl-tRNA aminoacylation
- positive regulation of TOR signaling cascade
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- endomembrane system
- cytosol
- endoplasmic reticulum
- aminoacyl-tRNA synthetase multienzyme complex
- lysosome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- leucine-tRNA ligase activity
- protein binding
- GTPase activator activity
- aminoacyl-tRNA editing activity
- glutamine-tRNA ligase activity