Dele1 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including HRI-mediated signaling; positive regulation of mitophagy; and response to iron ion starvation. Located in mitochondrion. Is expressed in heart. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dele1 |
| Official Name | DAP3 binding cell death enhancer 1 [Source:MGI Symbol;Acc:MGI:1914089] |
| Ensembl ID | ENSMUSG00000024442 |
| Bio databases IDs | |
| Aliases | DAP3 binding cell death enhancer 1 |
| Synonyms | 0610009O20Rik, 2700004E22Rik, DAP3 binding cell death enhancer 1, DELE, DELE1(L), KIAA0141, RGD735029 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dele1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein kinase binding
- Sel1-like repeats
- protein binding
- Sel1 repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- response by
- induction in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dele1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase activator activity
- protein binding