Dscam Gene Summary [Mouse]
Enables netrin receptor binding activity and protein tyrosine kinase binding activity. Involved in several processes, including netrin-activated signaling pathway; neuron development; and positive regulation of axon extension involved in axon guidance. Acts upstream of or within several processes, including dendrite development; glutamatergic synaptic transmission; and post-embryonic retina morphogenesis in camera-type eye. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Is expressed in several structures, including central nervous system; peripheral nervous system; sensory organ; skin; and testis. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dscam |
| Official Name | DS cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1196281] |
| Ensembl ID | ENSMUSG00000050272 |
| Bio databases IDs | |
| Aliases | DS cell adhesion molecule |
| Synonyms | 4932410A21Rik, CHD2, CHD2-42, CHD2-52, DSCAM1, DS cell adhesion molecule, LOC100360483, LOC686040 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dscam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
- immunoglobulin domain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- Fibronectin type 3 domain
- FN3
- Immunoglobulin like
- intracellular domain
- PDZ binding motif
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Dscam gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-small cell lung cancer
- Hirschsprung disease
- Alzheimer disease
- survival
- hereditary disorder
- schizophrenia
- hypertension
- progression free survival
- narcolepsy
phenotypes
- abnormal amacrine cell morphology
- abnormal axon fasciculation
- abnormal brain commissure morphology
- abnormal brain internal capsule morphology
- abnormal brain morphology
- abnormal brain ventricle morphology
- abnormal breathing pattern
- abnormal central pattern generator function
- abnormal cerebellar foliation
- abnormal cerebral aqueduct morphology
- abnormal cerebral cortex morphology
- abnormal corpus callosum morphology
- abnormal cranial cavity morphology
- abnormal dopaminergic neuron morphology
- abnormal eye electrophysiology
- abnormal gait
- abnormal hippocampus morphology
- abnormal lateral ventricle morphology
- abnormal maternal behavior
- abnormal motor learning
- abnormal neurite morphology
- abnormal posture
- abnormal respiration
- abnormal resting posture
- abnormal retina morphology
- abnormal retinal bipolar cell morphology
- abnormal retinal cone bipolar cell morphology
- abnormal retinal ganglion cell morphology
- abnormal retinal ganglion layer morphology
- abnormal retinal inner nuclear layer morphology
- abnormal retinal inner nuclear layer thickness
- abnormal retinal inner plexiform layer morphology
- abnormal retinal neuronal layer morphology
- abnormal somatic nervous system physiology
- apnea
- decreased pulmonary respiratory rate
- decreased striatum size
- delayed eyelid opening
- delayed parturition
- dilated brain ventricles
- dilated third ventricle
- disorganized retinal ganglion layer
- disorganized retinal inner nuclear layer
- domed cranium
- enlarged brain ventricles
- enlarged lateral ventricles
- hydrocephaly
- impaired balance
- impaired coordination
- impaired swimming
- increased neuron number
- increased retinal ganglion cell number
- kyphosis
- muscle hypertonia
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
- respiratory distress
- retina hyperplasia
- seizures
- small ears
- small olfactory bulb
- thick retinal ganglion layer
- thin cerebral cortex
- trunk curl
role in cell
- expression in
- activation in
- density
- number
- quantity
- development
- morphogenesis
- morphology
- abnormal morphology
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- growth cone
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dscam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphorylation
- negative regulation of cell adhesion
- nervous system development
- axon guidance
- camera-type eye photoreceptor cell differentiation
- cell adhesion
- homophilic cell adhesion
- positive regulation of axon extension involved in axon guidance
- dendrite morphogenesis
- synapse assembly
- central nervous system development
- locomotory behavior
- dendrite self-avoidance
- retina layer formation
- post-embryonic retina morphogenesis in camera-type eye
- netrin-activated signaling pathway
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- membrane
- neuronal cell body
- synapse
- extracellular region
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding