Grp Gene Summary [Rat]
Predicted to enable neuropeptide hormone activity. Involved in several processes, including cellular response to sodium phosphate; negative regulation of cation channel activity; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in extracellular space. Is active in neuronal dense core vesicle. Biomarker of chronic kidney disease. Orthologous to human GRP (gastrin releasing peptide). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grp |
| Official Name | gastrin releasing peptide [Source:RGD Symbol;Acc:621740] |
| Ensembl ID | ENSRNOG00000016999 |
| Bio databases IDs | |
| Aliases | gastrin releasing peptide |
| Synonyms | BLP, BN, Gastrin-releasing Peptide, GRP-10, preproGRP, proGRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bombesin-like peptide
- protein binding
- neuropeptide hormone
- growth factor
Pathways
Biological processes and signaling networks where the Grp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- schizophrenia
- hyperplasia
- hypothermia
- hyperglycemia
- tumorigenesis
- rheumatoid arthritis
- hyperinsulinism
- atopic dermatitis
role in cell
- expression in
- activation in
- proliferation
- cell cycle progression
- growth
- degranulation
- synthesis in
- morphology
- formation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- neurites
- secretory granules
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- response to external biotic stimulus
- neuropeptide signaling pathway
- positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of behavioral fear response
- ossification
- signal transduction
- positive regulation of peptide hormone secretion
- regulation of gene expression
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule lumen
- extracellular region
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- receptor binding