Nmbr Gene Summary [Mouse]
Predicted to enable neuropeptide receptor activity. Involved in several processes, including antiviral innate immune response; negative regulation of interleukin-6 production; and positive regulation of osteoclast proliferation. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in brain; dentate gyrus subgranular zone; lung; lung epithelium; and lung mesenchyme. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmbr |
| Official Name | neuromedin B receptor [Source:MGI Symbol;Acc:MGI:1100525] |
| Ensembl ID | ENSMUSG00000019865 |
| Bio databases IDs | |
| Aliases | neuromedin B receptor |
| Synonyms | BB1, BB182387, BB1R, Bb1 Receptor, BRS1, LOC100361806, LOC102552086, LOC681272, neuromedin B receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nmbr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- bombesin receptor
Pathways
Biological processes and signaling networks where the Nmbr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- sneeze
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nmbr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- bombesin receptor signaling pathway
- positive regulation of interferon-alpha production
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of osteoclast proliferation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bombesin receptor activity
- neuropeptide receptor activity