Cidec Gene Summary [Mouse]
Enables lipid transfer activity; molecular condensate scaffold activity; and phospholipid binding activity. Involved in lipid droplet fusion; lipid storage; and negative regulation of lipid metabolic process. Is active in lipid droplet. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cidec |
| Official Name | cell death-inducing DFFA-like effector c [Source:MGI Symbol;Acc:MGI:95585] |
| Ensembl ID | ENSMUSG00000030278 |
| Bio databases IDs | |
| Aliases | cell death-inducing DFFA-like effector c |
| Synonyms | Adipoocyte-specific, cell death-inducing DFFA-like effector c, CIDE-3, FPLD5, FSP27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cidec often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- binding protein
- CIDE-N domain
- protein binding activity, bridging
- CIDE_N
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Ullrich congenital muscular dystrophy
- diabetic nephropathy
- obesity
- insulin resistance
- cardiac fibrosis
- hepatic steatosis
- familial partial lipodystrophy type 5
- aortic valve calcification
- adult-onset obesity
- myocardial hypertrophy
phenotypes
- abnormal bone mineralization
- abnormal optic disk morphology
- abnormal tail movements
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgG1 level
- decreased T cell number
- decreased body weight
- decreased circulating alkaline phosphatase level
- decreased granulocyte number
- decreased monocyte cell number
- decreased total body fat amount
- increased B cell number
- increased circulating amylase level
- increased circulating calcium level
- increased circulating cholesterol level
- increased circulating serum albumin level
- increased circulating total protein level
- increased heart weight
- increased hemoglobin content
- increased lean body mass
- increased leukocyte cell number
- increased mean corpuscular volume
- increased total body fat amount
- thrombocytopenia
- abnormal adipose tissue amount
- abnormal blood homeostasis
- abnormal brown adipose tissue morphology
- abnormal circulating alkaline phosphatase level
- abnormal fat cell morphology
- abnormal fat pad morphology
- abnormal gonadal fat pad morphology
- abnormal lean body mass
- abnormal white adipose tissue morphology
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating ketone body level
- decreased circulating leptin level
- decreased circulating triglyceride level
- decreased gonadal fat pad weight
- decreased inguinal fat pad weight
- decreased mesenteric fat pad weight
- decreased retroperitoneal fat pad weight
- decreased subcutaneous adipose tissue amount
- decreased susceptibility to age related obesity
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased white adipose tissue amount
- enhanced lipolysis
- impaired adaptive thermogenesis
- improved glucose tolerance
- increased body temperature
- increased energy expenditure
- increased food intake
- increased insulin sensitivity
- increased oxygen consumption
- increased respiratory quotient
- no abnormal phenotype detected
role in cell
- expression in
- growth
- apoptosis
- phosphorylation in
- number
- activation in
- activity
- formation
- accumulation
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lipid droplets
- cytosol
- lipid droplet contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cidec gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- apoptotic process
- lipid particle organization
- regulation of apoptotic process
- negative regulation of triglyceride metabolic process
- execution phase of apoptosis
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidic acid binding