Serpina12 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Located in extracellular space and plasma membrane. Is expressed in back skin. Orthologous to human SERPINA12 (serpin family A member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpina12 |
| Official Name | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 [Source:MGI Symbol;Acc:MGI:1915304] |
| Ensembl ID | ENSMUSG00000041567 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 |
| Synonyms | 4632419J12Rik, OL-64, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12, serine (or cysteine) peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 12, serpin family A member 12, VASPIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpina12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serpina12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- breast cancer
- hepatic steatosis
- weight gain
- disorder of pregnancy
role in cell
- abnormal morphology
- size
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serpina12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- protein kinase B signaling cascade
- positive regulation of insulin receptor signaling pathway
- negative regulation of lipid biosynthetic process
- lipid biosynthetic process
- negative regulation of gluconeogenesis
- negative regulation of endopeptidase activity
- positive regulation of protein kinase B signaling cascade
- regulation of triglyceride metabolic process
- regulation of cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity