Kif20b Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Acts upstream of or within neural tube closure; regulation of establishment of protein localization; and regulation of neuron migration. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and spindle midzone. Is expressed in cerebral cortex marginal layer; cerebral cortex ventricular layer; cortical plate; and cortical subplate. Used to study microcephaly. Orthologous to human KIF20B (kinesin family member 20B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif20b |
| Official Name | kinesin family member 20B [Source:MGI Symbol;Acc:MGI:2444576] |
| Ensembl ID | ENSMUSG00000024795 |
| Bio databases IDs | |
| Aliases | kinesin family member 20B |
| Synonyms | 33cex, C330014J10RIK, circKIF20B, CT90, DKFZp434B0435, kinesin family member 20B, KRMP1, magoo, M-phase phosphoprotein 1, MPHOSPH1, MPP-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif20b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helix-rich Mycoplasma protein
- enzyme
- motor domain
- ATPase
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- plus-end-directed kinesin ATPase
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- rad50
- alpha helix
- WW domain binding
- Myosin tail
- SWI5-dependent HO expression protein 3
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- RBD_KIF20A-like
- Kinesin motor, catalytic domain
- microtubule binding
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Trichohyalin-plectin-homology domain
- Kinesin motor domain
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- Outer membrane protein (OmpH-like)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetic nephropathy
- colorectal cancer
- non-small cell lung cancer
- bladder carcinoma
- ocular hypertension
role in cell
- apoptosis
- growth
- expression in
- generation in
- proliferation
- G1 phase
- gefitinib resistance
- quantity
- S phase
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- contractile rings
- midbody
- cytoplasmic bridges
- cytosol
- nucleoplasm
- nucleoli
- spindle pole
- growth cone
- neuritic shafts
- membrane processes
- central spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif20b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- regulation of mitosis
- protein localization to microtubule
- positive regulation of cell proliferation
- neuron projection morphogenesis
- microtubule-based movement
- cell division
- neural tube closure
- regulation of cell cycle
- positive regulation of cytokinesis
- positive regulation of neuron migration
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- contractile ring
- kinesin complex
- nucleolus
- microtubule
- nucleoplasm
- growth cone
- nucleus
- intercellular bridge
- spindle midzone
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- protein homodimerization activity
- plus-end-directed microtubule motor activity
- microtubule binding
- WW domain binding