Slc29a2 Gene Summary [Mouse]
Enables neurotransmitter transmembrane transporter activity; purine nucleoside transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in neurotransmitter uptake and nucleoside transport. Acts upstream of or within nucleoside transport. Is active in plasma membrane. Orthologous to human SLC29A2 (solute carrier family 29 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc29a2 |
| Official Name | solute carrier family 29 (nucleoside transporters), member 2 [Source:MGI Symbol;Acc:MGI:1345278] |
| Ensembl ID | ENSMUSG00000024891 |
| Bio databases IDs | |
| Aliases | solute carrier family 29 (nucleoside transporters), member 2 |
| Synonyms | DER12, ENT2, hENT2, HNP36, LOC108348052, mENT2, rENT2, solute carrier family 29 member 2, solute carrier family 29 (nucleoside transporters), member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc29a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- cytidine transporter
- nucleobase transporter
- purine nucleoside transporter
- nucleoside transporter
- Equilibrative Nucleoside Transporter (ENT)
- uracil transporter
- guanine transporter
- neurotransmitter transporter
- adenine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
regulated by
- insulin
- methylprednisolone
- MIR4717
- BMP15
- KF24345
- pergolide
- PKC alpha/beta
regulates
- uracil
- nitrogenous base
- doxifluridine
- guanine
- uridine
- adenine
- nucleoside
- hypoxanthine
- 3-iodothyronamine
- AICAR
role in cell
- cell death
- uptake in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc29a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thymine transport
- nucleobase transport
- uridine transport
- cytidine transport
- hypoxanthine transport
- purine nucleoside transport
- inosine transport
- neurotransmitter transport
- drug transmembrane transport
- pyrimidine-containing compound transmembrane transport
- neurotransmitter uptake
- nucleoside transport
- adenosine transport
- guanine transport
- adenine transport
Cellular Component
Where in the cell the gene product is active
- nucleolus
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside transmembrane transporter activity
- uridine transmembrane transporter activity
- neurotransmitter transporter activity
- cytidine transmembrane transporter activity
- purine nucleoside transmembrane transporter activity
- uracil transmembrane transporter activity
- guanine transmembrane transporter activity
- adenine transmembrane transporter activity
- nucleobase transmembrane transporter activity