Serinc2 Gene Summary [Mouse]
Predicted to enable phospholipid scramblase activity. Predicted to be involved in phosphatidylserine metabolic process and plasma membrane phospholipid scrambling. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human SERINC2 (serine incorporator 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serinc2 |
| Official Name | serine incorporator 2 [Source:MGI Symbol;Acc:MGI:1919132] |
| Ensembl ID | ENSMUSG00000023232 |
| Bio databases IDs | |
| Aliases | serine incorporator 2 |
| Synonyms | 2310004K20RIK, AW121759, FKSG84, PRO0899, serine incorporator 2, TDE2, TDE2L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serinc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid scramblase
- protein binding activity, bridging
- Serine incorporator (Serinc)
- enzyme activator activity
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- irritable bowel syndrome
- glioblastoma
- glioblastoma cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- liver cirrhosis
regulates
- phospholipid
- sphingolipid
- phosphatidylserine
role in cell
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serinc2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane