Minpp1 Gene Summary [Mouse]
Enables inositol phosphate phosphatase activity. Is active in endoplasmic reticulum lumen and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Minpp1 |
| Official Name | multiple inositol polyphosphate histidine phosphatase 1 [Source:MGI Symbol;Acc:MGI:1336159] |
| Ensembl ID | ENSMUSG00000024896 |
| Bio databases IDs | |
| Aliases | multiple inositol polyphosphate histidine phosphatase 1 |
| Synonyms | HIPER1, MINPP2, MIPP, multiple inositol polyphosphate histidine phosphatase 1, multiple inositol-polyphosphate phosphatase 1, PCH16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Minpp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2,3-bisphosphoglycerate 3-phosphatase
- ER targeting sequence
- Histidine phosphatase superfamily (branch 2)
- protein binding
- phosphoinositide phosphatase
- multiple inositol-polyphosphate phosphatase
- ER retention sequence
- inositol trisphosphate phosphatase
- inositol bisphosphate phosphatase
- phosphatase
- inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase
- Histidine phosphatase domain
- inositol-1,4,5,6-tetrakisphosphate 6-phosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pontocerebellar hypoplasia type 16
- chronic lymphocytic leukemia
- non-syndromic congenital pontocerebellar hypoplasia
- follicular thyroid carcinoma
- follicular thyroid cancer
- nonmedullary thyroid cancer type 2
regulates
- Ca2+
- phytic acid
- inositol-1,3,4,5,6-pentakisphosphate
- 1,4,5-IP3
- inositol phosphate
role in cell
- growth
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Plasma Membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Minpp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- bone mineralization
- ossification
- cellular cation homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acid phosphatase activity
- inositol-hexakisphosphate phosphatase activity
- protein binding
- inositol trisphosphate phosphatase activity
- 4-phytase activity
- inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
- inositol pentakisphosphate phosphatase activity
- inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
- inositol hexakisphosphate 2-phosphatase activity
- bisphosphoglycerate 3-phosphatase activity
- inositol bisphosphate phosphatase activity
- 3-phytase activity
- inositol phosphate phosphatase activity