Plxna2 Gene Summary [Mouse]
Enables identical protein binding activity and semaphorin receptor activity. Involved in several processes, including chordate embryonic development; limb bud formation; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway; centrosome localization; and cerebellar granule cell precursor tangential migration. Located in plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and peripheral nervous system. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Plxna2 |
| Official Name | plexin A2 [Source:MGI Symbol;Acc:MGI:107684] |
| Ensembl ID | ENSMUSG00000026640 |
| Bio databases IDs | |
| Aliases | plexin A2 |
| Synonyms | 2810428A13Rik, FLJ30634, mKIAA0463, OCT, PlexA2, Plexin a2, PLXN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- identical protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- cytoplasmic domain
- TIG domain found in plexin
- IPT/TIG domain
- semaphorin receptor
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Plxna2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- schizophrenia
- pancreatic ductal adenocarcinoma
- COVID-19
- androgenic alopecia
- pancreatic epithelial cancer
- ductal pancreatic cancer
- atypical cerebral palsy
- restless legs syndrome
- cleft lip
role in cell
- phosphorylation in
- invasion by
- proliferation
- expression in
- migration
- G2/M phase
- contraction
- length
- function
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- cellular membrane
- synaptic vesicles
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxna2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- regulation of cell shape
- cerebellar granule cell precursor tangential migration
- negative regulation of cell adhesion
- limb bud formation
- pharyngeal system development
- centrosome localization
- positive regulation of axonogenesis
- somitogenesis
- regulation of GTPase activity
- regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- semaphorin receptor activity