Dpp4 Gene Summary [Mouse]
Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpp4 |
| Official Name | dipeptidylpeptidase 4 [Source:MGI Symbol;Acc:MGI:94919] |
| Ensembl ID | ENSMUSG00000035000 |
| Bio databases IDs | |
| Aliases | dipeptidylpeptidase 4 |
| Synonyms | ADABP, ADCP2, Adenosine Deaminase Binding, CD26, DDP4, Dipeptidylaminopeptidase IV, dipeptidyl peptidase 4, Dipeptidyl Peptidase IV, DPPIV, Glycylprolyl Beta-Naphthylamidase, Glycylprolyl β-Naphthylamidase, PEPTIDYLDIPEPTIDASE IV, THAM, TP103 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Dipeptidyl peptidase IV (DPP IV) low complexity region
- chemorepellant
- viral receptor
- gelatin binding domain
- peptidase
- identical protein binding
- alpha/beta hydrolase fold domain
- cytoplasmic domain
- intracellular domain
- dipeptidyl-peptidase
- cysteine rich domain
- extracellular domain
- Prolyl oligopeptidase family
- beta propeller
- protease binding
- catalytic domain
- protein binding
- receptor binding
- caveolin binding domain
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- serine endopeptidase
- serine-type peptidase
- dipeptidyl-peptidase IV
- lumenal domain
- transmembrane domain
- collagen binding
- protein homodimerization
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Dpp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- neoplasia
- Parkinson disease
- non-small cell lung cancer
- obesity
- nonalcoholic fatty liver disease
- non-insulin-dependent diabetes mellitus
- asthma
- impaired glucose tolerance
- diabetes mellitus
role in cell
- phosphorylation in
- cell death
- apoptosis
- expression in
- proliferation
- cell cycle progression
- growth
- differentiation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- pH resistant lipid raft fraction
- tetraspanin-enriched microdomain
- Cytoplasm
- invadopodia
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- intercellular junctions
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- Golgi membrane
- endocytotic vesicle
- membrane rafts
- plasma
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative chemotaxis
- membrane fusion
- locomotory exploration behavior
- T cell costimulation
- negative regulation of neutrophil chemotaxis
- positive regulation of cell proliferation
- T cell activation
- cell adhesion
- endothelial cell migration
- virion attachment, binding of host cell surface receptor
- behavioral fear response
- response to hypoxia
- viral entry into host cell via receptor-mediated endocytosis
- negative regulation of extracellular matrix disassembly
- proteolysis
- regulation of cell-cell adhesion mediated by integrin
- peptide hormone processing
Cellular Component
Where in the cell the gene product is active
- extracellular region
- lysosomal membrane
- plasma membrane
- cell surface
- intercellular canaliculus
- endocytic vesicle
- extracellular vesicular exosome
- focal adhesion
- membrane
- membrane raft
- apical plasma membrane
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- protease binding
- viral receptor activity
- aminopeptidase activity
- chemorepellent activity
- dipeptidyl-peptidase activity
- receptor binding