Slc25a4 Gene Summary [Mouse]
Enables ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including nucleotide transmembrane transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a4 |
| Official Name | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [Source:MGI Symbol;Acc:MGI:1353495] |
| Ensembl ID | ENSMUSG00000031633 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 |
| Synonyms | AAC1, Adc, ADT1, ANC1, ANT, ANT 1, mANC1, Mitochondrial adenine nucleotide translocator, MTDPS12, MTDPS12A, PEO2, PEO3, PEOA2, solute carrier family 25 member 4, solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4, T1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- Mitochondrial carrier protein
- enzyme binding
- protein binding
- ATP/ADP antiporter
- adenine transporter
- transporter
- oxidative phosphorylation uncoupler
Pathways
Biological processes and signaling networks where the Slc25a4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- prostate cancer
- lung squamous cell carcinoma
- lung adenocarcinoma formation
- autosomal recessive cardiomyopathic type mitochondrial DNA depletion syndrome 12b
- breast cancer
- autosomal dominant mitochondrial DNA depletion syndrome 12a cardiomyopathic type
- autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2
role in cell
- growth
- cell death
- cell viability
- apoptosis
- migration
- proliferation
- regulation
- morphology
- permeability
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cristae-like membrane
- mitochondrial envelope
- cellular membrane
- inner membrane
- Plasma Membrane
- Mitochondria
- myofilaments
- mitochondrial membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- nuclear envelope
- membrane rafts
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- apoptotic mitochondrial changes
- ADP transport
- regulation of mitochondrial membrane permeability
- adenine transport
- negative regulation of necroptosis
- mitochondrial genome maintenance
Cellular Component
Where in the cell the gene product is active
- mitochondrial permeability transition pore complex
- mitochondrial membrane
- membrane
- mitochondrion
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion transmembrane transporter activity
- ATP:ADP antiporter activity
- oxidative phosphorylation uncoupler activity
- adenine transmembrane transporter activity