Hhex Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within several processes, including forebrain development; hepaticobiliary system development; and tube morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gut; liver and biliary system; and metanephros. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Hhex |
| Official Name | hematopoietically expressed homeobox [Source:MGI Symbol;Acc:MGI:96086] |
| Ensembl ID | ENSMUSG00000024986 |
| Bio databases IDs | |
| Aliases | hematopoietically expressed homeobox |
| Synonyms | haematopoietically expressed homeobox, hematopoietically expressed homeobox, HEX, Hex1, HHEX-RS2, HMPH, HOX11L-PEN, PRH, PRHX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hhex often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- alpha helix
- DNA bending protein
- transcription factor binding
- homeolike domain
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- proline rich domain
- eukaryotic initiation factor 4E binding
- TATA-binding protein binding
- translation regulator
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- protein homodimerization
- eIF4E binding domain
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- insomnia
- organismal death
- immunosuppression
- obesity
- stenosis
- hypoplasia
- double outlet right ventricle
- non-insulin-dependent diabetes mellitus
role in cell
- proliferation
- expression in
- differentiation
- migration
- development
- abnormal morphology
- invasion by
- survival
- binding in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nuclear bodies
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hhex gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- B cell differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
- mRNA export from nucleus
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of transcription by competitive promoter binding
- positive regulation of transcription, DNA-dependent
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cell differentiation
- Wnt receptor signaling pathway
- negative regulation of transcription by transcription factor localization
- regulation of leukocyte proliferation
- DNA conformation change
- positive regulation of Wnt receptor signaling pathway
- protein localization to nucleus
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- protein-DNA complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- TBP-class protein binding
- eukaryotic initiation factor 4E binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity