Cx3cl1 Gene Summary [Mouse]
Enables CX3C chemokine receptor binding activity. Acts upstream of or within several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of transforming growth factor beta1 production. Located in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cx3cl1 |
| Official Name | chemokine (C-X3-C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:1097153] |
| Ensembl ID | ENSMUSG00000031778 |
| Bio databases IDs | |
| Aliases | chemokine (C-X3-C motif) ligand 1 |
| Synonyms | AB030188, ABCD-3, C3Xkine, CX3C, CX3CL, C-X3-C motif chemokine ligand 1, CXC3, CXC3C, CXC3 CHEMOKINE precursor, D8Bwg0439e, FK, FKN, fractalkine, neurotactin, NTN, NTT, SCYD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cx3cl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- chemoattractant
- chemokine receptor binding
- CX3C chemokine domain
- CXCR1 chemokine receptor binding
- signal peptide
- chemokine domain
- protein binding
- receptor binding
- cytokine
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- integrin binding
- transmembrane domain
- mucin domain
Pathways
Biological processes and signaling networks where the Cx3cl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- prostate cancer
- obesity
- non-insulin-dependent diabetes mellitus
- psoriasis
- atherosclerosis
- migraines
- mild cognitive impairment
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- expression in
- production in
- proliferation
- survival
- apoptosis
- phosphorylation in
- function
- activation in
- binding in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- neurites
- recycling endosomes
- cellular protrusions
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cx3cl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glutamate receptor signaling pathway
- positive chemotaxis
- negative regulation of interleukin-1 alpha production
- negative regulation of interleukin-1 beta production
- positive regulation of GTPase activity
- cell chemotaxis
- inflammatory response
- immune response
- lymphocyte chemotaxis
- negative regulation of cell-substrate adhesion
- eosinophil chemotaxis
- regulation of synaptic plasticity
- positive regulation of neuron projection development
- negative regulation of tumor necrosis factor production
- G-protein coupled receptor signaling pathway
- positive regulation of inflammatory response
- cell-cell signaling
- positive regulation of neuroblast proliferation
- negative regulation of interleukin-6 production
- positive regulation of transforming growth factor beta1 production
- leukocyte migration involved in inflammatory response
- positive regulation of cell-matrix adhesion
- positive regulation of actin filament bundle assembly
- neuron remodeling
- regulation of neurogenesis
- regulation of lipopolysaccharide-mediated signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
- autocrine signaling
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell adhesion
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle cell proliferation
- chemotaxis
- response to ischemia
- cytokine-mediated signaling pathway
- negative regulation of neuron migration
- angiogenesis involved in wound healing
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of calcium-independent cell-cell adhesion
- positive regulation of MAPK cascade
- positive regulation of release of sequestered calcium ion into cytosol
- defense response
- microglial cell activation
- neuron homeostasis
- negative regulation of apoptotic process
- chemokine-mediated signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- leukocyte adhesive activation
- neutrophil chemotaxis
- leukocyte chemotaxis
- negative regulation of apoptotic signaling pathway
- integrin activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- membrane
- neuronal cell body
- extracellular region
- neuron projection
- cell projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- CX3C chemokine receptor binding
- protein binding
- CCR chemokine receptor binding
- chemoattractant activity
- CXCR1 chemokine receptor binding
- integrin binding
- chemokine activity
- receptor binding