Mgp Gene Summary [Mouse]
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. This protein also inhibits angiogenesis. Mice lacking a functional copy of this gene exhibit impaired differentiation of endothelial cells, reduced stature, and calcification and rupture of the vasculature leading to premature death. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Mgp |
| Official Name | matrix Gla protein [Source:MGI Symbol;Acc:MGI:96976] |
| Ensembl ID | ENSMUSG00000030218 |
| Bio databases IDs | |
| Aliases | matrix Gla protein |
| Synonyms | GIG36, LOC223886, Matrix gamma-carboxyglutamate, Matrix gla, matrix Gla protein, Matrix γ-carboxyglutamate, MGLAP, NTI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- structural constituent of bone
- calcium ion binding
- extracellular matrix structural constituent
- protein binding
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- weight gain
- non-insulin-dependent diabetes mellitus
- bleeding
- glaucoma
- endometriosis
- heart failure with preserved ejection fraction
- Keutel syndrome
- endometrioid carcinoma
- endometrioid cancer
role in cell
- proliferation
- apoptosis
- expression in
- phosphorylation in
- migration
- function
- differentiation
- accumulation in
- mineralization
- transdifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Endoplasmic Reticulum
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cartilage condensation
- ossification
- cell differentiation
- regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- structural constituent of bone
- extracellular matrix structural constituent