Clcc1 Gene Summary [Mouse]
Enables chloride channel activity and identical protein binding activity. Involved in endoplasmic reticulum calcium ion homeostasis. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 32. Orthologous to human CLCC1 (chloride channel CLIC like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcc1 |
| Official Name | chloride channel CLIC-like 1 [Source:MGI Symbol;Acc:MGI:2385186] |
| Ensembl ID | ENSMUSG00000027884 |
| Bio databases IDs | |
| Aliases | chloride channel CLIC-like 1 |
| Synonyms | chloride channel CLIC-like 1, ERAC1, KIAA0761, MCLC, RP32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mid-1-related chloride channel (MCLC)
- chloride channel
- protein binding
- identical protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- chloride
- ATF6
regulated by
disease
- retinitis pigmentosa type 32
- major depression
- retinal dystrophy
phenotypes
- abnormal chorioallantoic fusion
- abnormal embryo size
- abnormal embryo turning
- embryonic lethality prior to tooth bud stage
- preweaning lethality complete penetrance
- abnormal cerebellar granule cell morphology
- abnormal cerebellar granule layer morphology
- abnormal fasting circulating glucose level
- abnormal retina morphology
- abnormal retinal inner nuclear layer morphology
- abnormal retinal inner plexiform layer morphology
- abnormal retinal outer nuclear layer morphology
- abnormal retinal outer plexiform layer morphology
- abnormal retinal photoreceptor layer morphology
- ataxia
- brain vacuoles
- cerebellum hypoplasia
- decreased a wave amplitude
- decreased b wave amplitude
- decreased cerebellar granule cell number
- decreased retinal cone cell number
- decreased skeletal muscle fiber diameter
- embryonic lethality complete penetrance
- increased endoplasmic reticulum stress
- muscular atrophy
- neurodegeneration
- skeletal muscle atrophy
- skeletal muscle fiber atrophy
role in cell
- activation in
- calcium homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clcc1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- endoplasmic reticulum membrane
- nuclear membrane
- intracellular membrane-bounded organelle
- membrane
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chloride channel activity