Lemd3 Gene Summary [Mouse]
Predicted to enable chromatin DNA binding activity. Acts upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Located in nuclear envelope. Is expressed in several structures, including allantois; foregut diverticulum endoderm; lateral plate mesoderm; neural plate; and primitive streak. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lemd3 |
| Official Name | LEM domain containing 3 [Source:MGI Symbol;Acc:MGI:3580376] |
| Ensembl ID | ENSMUSG00000048661 |
| Bio databases IDs | |
| Aliases | LEM domain containing 3 |
| Synonyms | LEM domain containing 3, MAN1, Msrb3, RGD1561001 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lemd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- LEM
- protein binding
- LEM domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatofibrosis lenticularis disseminata
- melorheostosis with osteopoikilosis
- hereditary disorder
- Tietze disease
- osteopoikilosis
- venous thromboembolism
- intracranial arteriovenous malformation
role in cell
- differentiation
- organization
- cell cycle progression
- myogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- inner nuclear membrane
- nuclear envelope
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lemd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of activin receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding